Dr. Matthew Walker, All Issues Sleep — The right way to Enhance Sleep, How Sleep Ties Into Alzheimer’s Illness and Weight Achieve, and How Drugs (Ambien, Trazodone,

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“Most of us assume that sleep advanced. However why ought to we make that assumption? Why isn’t it that sleep was the default state when life emerged, and it was wakefulness that advanced?”

— Dr. Matthew Walker

Matthew Walker, PhD (@sleepdiplomat), is professor of neuroscience on the College of California Berkeley and founder and director of the college’s Center for Human Sleep Science. Walker is the writer of the New York Occasions and worldwide bestseller Why We Sleep: Unlocking the Power of Sleep and Dreams, which was lately listed by Invoice Gates as one among his high 5 books of the yr. His TED Discuss, “Sleep is Your Superpower,” has garnered greater than 17 million views. 

He has acquired quite a few funding awards from the Nationwide Science Basis and the Nationwide Institutes of Well being and is a Kavli Fellow of the Nationwide Academy of Sciences. In 2020, Walker was awarded the Carl Sagan Prize for Science Achievements. Walker’s analysis examines the influence of sleep on human well being and illness. He has been featured on quite a few tv and radio shops together with 60 Minutes, Nat Geo TV, NOVA Science, NPR, and the BBC. He’s additionally the host of the 5-star-rated podcast The Matt Walker Podcast, which is all about sleep, the mind, and the physique.

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The transcript of this episode could be discovered right here. Transcripts of all episodes could be discovered right here.

#650: Dr. Matthew Walker, All Issues Sleep — The right way to Enhance Sleep, How Sleep Ties Into Alzheimer’s Illness and Weight Achieve, and How Drugs (Ambien, Trazodone, and many others.), Caffeine, THC/CBD, Psychedelics, Train, Good Medication, Fasting, and Extra Have an effect on Sleep

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Wish to hear one other podcast episode with somebody who received’t relaxation till you get a great night time’s sleep? Take heed to my dialog with neuroscientist and Stanford College professor Dr. Andrew Huberman, by which we mentioned timing circadian biology to intensify the optimistic and eradicate the unfavourable, the best time for morning mild publicity, what he recommends over melatonin as a sleep support, the non-sleep deep remainder of yoga nidra, utilizing physiological sighs to scale back stress, the way forward for useful mind change, cage diving with nice white sharks, and rather more.

#521: Dr. Andrew Huberman — A Neurobiologist on Optimizing Sleep, Enhancing Efficiency, Lowering Anxiousness, Rising Testosterone, and Utilizing the Physique to Management the Thoughts

What was your favourite quote or lesson from this episode? Please let me know in the comments.



  • Join with Dr. Matthew Walker:

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  • [05:55] Sleep and Alzheimer’s illness.
  • [19:55] What causes the decline of deep sleep as we age?
  • [24:36] Are there any identified species that don’t require sleep?
  • [29:15] Mind stimulation for extra deep sleep, much less insomnia.
  • [41:01] Suggestions for higher sleep with out laboratory finances or entry.
  • [51:45] Best sorts of train for selling deep sleep.
  • [53:51] Matt’s up to date ideas on caffeine and sleep.
  • [1:11:12] Hashish (CBD, THC, CBN) and sleep.
  • [1:30:18] A crowdsourcing request of listeners.
  • [1:36:17] If the mattress’s a-rocking…
  • [1:41:45] The Da Vinci Code magic sleep machine.
  • [1:46:04] DARPA innovation.
  • [1:46:32] Guaranteeing correct perform within the glymphatic system.
  • [1:50:42] Psychedelics and sleep.
  • [2:01:20] How sleep impacts meals consumption and weight fluctuation.
  • [2:10:46] Orexin, I reckon.
  • [2:22:11] Fainting goats and narcolepsy.
  • [2:25:36] Modafinil.
  • [2:30:32] How sleep drugs have an effect on sleep high quality.
  • [2:36:16] Trazodone.
  • [2:46:26] Perilous polypharmacy.
  • [2:49:04] Pregabalin and gabapentin.
  • [2:54:33] The psychological worth of emergency sleep drugs for insomniacs.
  • [2:58:16] CBTI and the balancing function of pharmacology.
  • [2:59:56] Parting ideas and what to anticipate from a future spherical two.


“If sleep is a lacking piece within the explanatory puzzle of ageing and Alzheimer’s illness, then possibly we are able to do one thing about it. Sleep is a modifiable issue.”

— Dr. Matthew Walker

“In biology it’s very uncommon that you just get a free lunch. And if you struggle biology, you usually lose.”

— Dr. Matthew Walker

“Night time after night time, for those who’re not cleaning the mind, it turns into like compounding curiosity on a mortgage, that it continues to escalate time and time once more, night time after night time. “

— Dr. Matthew Walker

“Most of us assume that sleep advanced. However why ought to we make that assumption? Why isn’t it that sleep was the default state when life emerged, and it was wakefulness that advanced?”

— Dr. Matthew Walker


DISCLAIMER: I’m not a health care provider, nor do I play one on the Web. Not one of the content material on this podcast constitutes medical recommendation. Please seek the advice of your physician earlier than contemplating something we talk about on this episode.

The Tim Ferriss Present is one of the preferred podcasts on the earth with greater than 900 million downloads. It has been chosen for “Better of Apple Podcasts” 3 times, it’s usually the #1 interview podcast throughout all of Apple Podcasts, and it has been ranked #1 out of 400,000+ podcasts on many events. To take heed to any of the previous episodes without cost, try this web page.