New data on Bone Loss in Menopause — Higher Bones

Are you vulnerable to dropping as much as 20% of your bone within the years round menopause?  Ladies with accelerated bone loss – referred to as “quick losers” in a brand new research – run a larger threat of creating osteoporosis and weaker bones than the common girl. The common girl solely loses 8-10% of her bone mass through the three years round menopause.

This new research exhibits there’s a simple technique to discover out for those who’re a “quick loser” of bone so you’ll be able to take motion to cease it.

Discover out for those who’re a “quick loser” of bone

Researchers centered on the usage of the N-telopeptide crosslinks take a look at — a urine take a look at — to assist determine ladies most in danger for larger and sooner bone loss.  As you lose bone, fragments of sure bone proteins present up within the urine; these are referred to as N-telopeptides (NTx). A lady with extra NTx protein fragments in her urine is probably going present process extra fast bone loss, and thus at greater threat of extreme menopausal bone loss.

Within the research, researchers regarded on the NTx bone breakdown ranges in some 500 early post-menopausal ladies who had been inside 1-2 years of getting their remaining interval. They discovered the next:

• The upper the urinary NTx degree, the sooner the speed of bone loss throughout the menopausal transition. This is smart: a better fee of bone breakdown would seemingly translate into larger bone loss.
• A urinary NTx degree above 65 nM BCE/mM Cr was discovered to determine quick bone losers pretty properly. To place this into context, the common premenopausal NTx degree is 36 nM BCE/mM Cr, and I’ve usually discovered postmenopausal ladies with a 50 NTx degree to be dropping ½ to 1% of bone mass per 12 months.
• The affiliation between early postmenopausal NTx and fee of bone loss was stronger on the backbone than on the hip. This once more is smart, as a result of the backbone is metabolically energetic trabecular bone, which usually loses mass years earlier than the hip does.
• Moreover, wanting backwards, it was discovered {that a} excessive urinary NTx in perimenopause was additionally related to a better fee of bone loss through the menopause transition.

Menopausal bone loss will not be unfold evenly over the 10-year transitional interval (5 years earlier than a girl’s final interval and 5 years after).  Most bone loss happens within the 3-year interval beginning 1 12 months earlier than a girl’s final interval and ending 2 years after her final interval — referred to as “trans menopause.”

What does this analysis imply for you?

When you’re noticing signs of perimenopause, like irregular intervals and scorching flashes or for those who underwent menopause lately (inside a few years), a easy take a look at of your urine NTx degree may help you determine an inclination to extreme bone loss.

When you’re experiencing extreme bone loss, you’ll be able to take steps to search out out why this is perhaps so and proper the state of affairs. After I work with particular person shoppers, that is precisely the type of work I do with them.

Extra data on the easy urine take a look at may be present in my quick video and related handbook. You can even order this take a look at on-line by our on-line inquiry system at our lab accomplice Evexia.

And since you’ll be able to’t actually know when the 12 months earlier than your final interval will happen till you even have skilled your final interval, it’s a good suggestion to get began immediately on a powerful Higher Bones Program on the first indicators of perimenopause.

Reference:

Shieh A, et al.  Urinary N-telopeptide and rate of bone loss over the menopause transition an early post-menopause. J Bone Miner Res. 2016;31(11):2057-2064.